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| Rêgo,Moacyr Jesus Barreto de Melo; Azoubel-Antunes,Adriana; Bezerra,Mariana Brayner-Cavalcanti Freire; Pereira,Michelly Cristiny; Silva,Juliana Cruz da; Lins,Thiago Ubiratan Lins e; Sarinho,Emanuel Sávio Cavalcanti; Amorim,Cézar Augusto da Cruz; Lima,Maria do Carmo Alves de; Galdino-Pitta,Marina Rocha; Pitta,Ivan da Rocha; Pitta,Maira Galdino da Rocha. |
| Allergic asthma is a chronic, complex inflammatory disease of the airway. Despite extensive studies on the immunomodulation of T helper (Th) cell pathways (i.e., Th1 and Th2) in asthma, little is known about the effects of Th17 pathway modulation, particularly that involving peroxisome proliferator-activated receptors (PPARs). In response, two new thiazolidinedione derivatives-namely, LPSF-GQ-147 and LPSF-CR-35 were synthesized and evaluated for their immunomodulatory effects on Th17-related cytokines, including interferon γ (IFNγ), interleukin IL-6, IL-17, and IL-22 in the peripheral blood mononuclear cells of asthmatic children. Both compounds were nontoxic even at high concentrations (i.e., 100 µM). The LPSF-CR-35 compound significantly reduced the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Asthma; Th17-related cytokines; Thiazolidinedione derivative. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000300602 |
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| Hwan-Hee,Jang; Su-Yeon,Cho; Mi-Ju,Kim; Jung-Bong,Kim; Sung-Hyen,Lee; Mee-Young,Lee; Young-Min,Lee. |
| BACKGROUND: Asthma is an increasing global health problem, and novel strategies to prevent or ameliorate the condition are needed. Here, the effects of 80 % ethanol extracts of Salvia plebeia R. Br. (SE) on an induced inflammatory response were investigated RESULTS: Salvia plebeia R. Br. inhibited production of pro-inflammatory cytokines, such as TNF-α and IL-6, as well as nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. NO and pro-inflammatory cytokine production was suppressed more effectively by SE of the aerial parts (SE-A) than of the roots (SE-R) of S. plebeia. In BEAS-2B cells, both SE-A and SE-R inhibited the increase in production of the inflammatory cytokines IL-6 and IL-8. We also investigated the antiasthmatic effects of SE in an... |
| Tipo: Journal article |
Palavras-chave: Anti-inflammatory; Asthma; Salvia plebeia. |
| Ano: 2016 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100041 |
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| Sun,F.J.; Zou,L.Y.; Tong,D.M.; Lu,X.Y.; Li,J.; Deng,C.B.. |
| This study aimed to investigate the association between ADAM metallopeptidase domain 33 (ADAM33) gene polymorphisms and the risk of childhood asthma. The relevant studies about the relationship between ADAM33 gene polymorphisms and childhood asthma were searched from electronic databases and the deadline of retrieval was May 2016. The single nucleotide polymorphisms (SNPs) of ADAM33 (rs511898, rs2280092, rs3918396, rs528557, rs2853209, rs44707, rs2280091 and rs2280089) were analyzed based on several models including the allele, codominant, recessive and dominant models. The results showed that the ADAM33 rs2280091 polymorphism in all four genetic models was associated with an increased risk of childhood asthma. Positive associations were also found between... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Childhood; Asthma; ADAM33; Gene polymorphisms; Asthma risk; Meta-analysis. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001000609 |
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| Chen,Wenli; Cui,Jiewei; Xiang,Guoan; Zhang,Jianpeng; Gao,Hongmei. |
| The published data on the association between MCP-1 -2518A>G polymorphism and asthma susceptibility are inconclusive. Therefore, we performed a meta-analysis to estimate the impact of MCP-1 -2518A>G polymorphism on asthma susceptibility. PubMed, Web of Science, Wanfang, and China National Knowledge Infrastructure (CNKI) databases were used to identify eligible studies. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to calculate the strength of association. Sensitivity analysis was performed to evaluate the influence of individual studies on the estimates of overall effect, and funnel plots and Egger's test were used to assess publication bias. Eight publications with 1562 asthma patients and 1574 controls were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: MCP-1; Polymorphism; Asthma; Susceptibility; Meta-analysis. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019001100602 |
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| Sadof, Matthew; Brandt, Sylvia J.. |
| Background: The Inner City Asthma Intervention (ICAI) was a national multi-center implementation of an evidence-based intervention to reduce asthma morbidity. Objective: This study describes mitigating behaviors and reported outcomes in families with asthma who completed the intervention and a post-intervention survey at one of the ICAI sites. Results: Eighty percent (0.72- 0.88, 95% confidence interval) of these families made five or more changes to mitigate exposure to environmental asthma triggers. The majority of families (0.84-0.96, 95% confidence interval) reported an improved awareness of asthma symptoms and less school absences, limitations of activity, unplanned doctor visits, and asthma related sleep disruption. |
| Tipo: Working or Discussion Paper |
Palavras-chave: Asthma; Health intervention; Health behavior; Health Economics and Policy; I12; I18; Z13. |
| Ano: 2007 |
URL: http://purl.umn.edu/14526 |
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| Faffe,D.S.. |
| Asthma is characterized by reversible airway obstruction, airway hyperresponsiveness, and airway inflammation. Although our understanding of its pathophysiological mechanisms continues to evolve, the relative contributions of airway hyperresponsiveness and inflammation are still debated. The first mechanism identified as important for asthma was bronchial hyperresponsiveness. In a second step, asthma was recognized also as an inflammatory disease, with chronic inflammation inducing structural changes or remodeling. However, persistence of airway dysfunction despite inflammatory control is observed in chronic severe asthma of both adults and children. More recently, a potential role for epithelial-mesenchymal communication or transition is emerging, with... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Asthma; Epithelial-mesenchymal unit; Bronchial hyperresponsiveness; Remodeling. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000900001 |
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| Silva,C.S.; Torres,L.A.G.M.M.; Rahal,A.; Terra Filho,J.; Vianna,E.O.. |
| Fitness improvement was used to compare morning with afternoon exercise periods for asthmatic children. Children with persistent moderate asthma (according to GINA criteria), 8 to 11 years old, were divided into 3 groups: morning training group (N = 23), afternoon training group (N = 23), and non-training group (N = 23). The program was based on twice a week 90-min sessions for 4 months. We measured the 9-min running distance, resting heart rate and abdominal muscle strength (sit-up number) before and after the training. All children took budesonide, 400 µg/day, and an on demand inhaled ß-agonist. The distance covered in 9 min increased (mean ± SEM) from 1344 ± 30 m by 248 ± 30 m for the morning group, from 1327 ± 30 m by 162 ± 20 m for the afternoon... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Asthma; Children; Chronotherapy; Exercise training; Circadian rhythm; Exercise-induced bronchospasm. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000100008 |
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| Vázquez Luna, Dinora. |
| En México, el desarrollo basado en la industria petrolera ha afectado los suelos y recursos naturales del sureste del país; sin embargo, no hay estudios que vinculen sus efectos sobre el desarrollo equitativo de los habitantes en zonas contaminadas. Por ello, el objetivo del trabajo fue analizar desde la perspectiva de género, los efectos sociales sobre el desarrollo equitativo de las familias, en cuatro zonas de los ejidos de Humanguillo, Tabasco (Rovirosa, El Paraíso, La Ceiba y Gurría), que se ubican a una distancia de 0.5, 2.5, 7 y 12 kilómetros al sur la petroquímica La Venta. Se realizaron encuestas con enfoque de género y de salud, donde las unidades de análisis fueron las familias. Se realizaron análisis de suelos para determinar los efectos de la... |
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Palavras-chave: Género; Asma; Contaminación ambiental; Hidrocarburos; Alergias; Gender; Asthma; Environmental pollution; Hydrocarbons; Allergies; Doctorado; Desarrollo Rural. |
| Ano: 2011 |
URL: http://hdl.handle.net/10521/422 |
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| Vázquez Luna, Dinora. |
| En México, el desarrollo basado en la industria petrolera ha afectado los suelos y recursos naturales del sureste del país; sin embargo, no hay estudios que vinculen sus efectos sobre el desarrollo equitativo de los habitantes en zonas contaminadas. Por ello, el objetivo del trabajo fue analizar desde la perspectiva de género, los efectos sociales sobre el desarrollo equitativo de las familias, en cuatro zonas de los ejidos de Humanguillo, Tabasco (Rovirosa, El Paraíso, La Ceiba y Gurría), que se ubican a una distancia de 0.5, 2.5, 7 y 12 kilómetros al sur la petroquímica La Venta. Se realizaron encuestas con enfoque de género y de salud, donde las unidades de análisis fueron las familias. Se realizaron análisis de suelos para determinar los efectos de la... |
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Palavras-chave: Género; Asma; Contaminación ambiental; Hidrocarburos; Alergias; Gender; Asthma; Environmental pollution; Hydrocarbons; Allergies; Doctorado; Desarrollo Rural. |
| Ano: 2011 |
URL: http://hdl.handle.net/10521/422 |
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| Santos,L.A.; Oliveira,M.A.; Faresin,S.M.; Santoro,I.L.; Fernandes,A.L.G.. |
| Asthma is a common chronic illness that imposes a heavy burden on all aspects of the patient's life, including personal and health care cost expenditures. To analyze the direct cost associated to uncontrolled asthma patients, a cross-sectional study was conducted to determine costs related to patients with uncontrolled and controlled asthma. Uncontrolled patient was defined by daytime symptoms more than twice a week or nocturnal symptoms during two consecutive nights or any limitations of activities, or need for relief rescue medication more than twice a week, and an ACQ score less than 2 points. A questionnaire about direct cost stratification in health services, including emergency room visits, hospitalization, ambulatory visits, and asthma medications... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Asthma; Health care costs; Health economy; Health care resources. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000700008 |
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| Mallmann,F.; Fernandes,A.K.; Ávila,E.M.; Nogueira,F.L.; Steinhorst,A.M.P.; Saucedo,D.Z.; Machado,F.J.; Raymundi,M.G.; Dalcin,P.T.R.; Menna Barreto,S.S.. |
| Early identification of patients who need hospitalization or patients who should be discharged would be helpful for the management of acute asthma in the emergency room. The objective of the present study was to examine the clinical and pulmonary functional measures used during the first hour of assessment of acute asthma in the emergency room in order to predict the outcome. We evaluated 88 patients. The inclusion criteria were age between 12 and 55 years, forced expiratory volume in the first second below 50% of predicted value, and no history of chronic disease or pregnancy. After baseline evaluation, all patients were treated with 2.5 mg albuterol delivered by nebulization every 20 min in the first hour and 60 mg of intravenous methylprednisolone.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Asthma; Outcome; Index; Prognosis; Emergency medicine. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000100006 |
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| Muller, Anetta; Kerenyi, Erika; Konyves, Erika. |
| Our research we organised at the Mátra Medical Institute in Mátraháza and Kékestetô among sick of asthma, COPD and hayfever. Our aim was to prove the effect of climate therapy in the Mátra Medical Institute. The subalpine climate plays a very important role in the cure of the Respiratory diseases, because to improve the life quality of the sick and reduce the medicine uses after the therapy. Our research took part more than 100 respiratory diseased. We analyse the data with SPSS.version 16. We measure average, standard deviation, Chi² probe, t-probe. You can see our results in the article. |
| Tipo: Journal Article |
Palavras-chave: Asthma; Pulmonology illnesses; Climate therapy; Life-quality; Marketing. |
| Ano: 2011 |
URL: http://purl.umn.edu/104664 |
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| Durigan,J.L.Q.; Peviani,S.M.; Russo,T.L.; Silva,A.C.D.; Vieira,R.P.; Martins,M.A.; Carvalho,C.R.F.; Salvini,T.F.. |
| We evaluated the effects of chronic allergic airway inflammation and of treadmill training (12 weeks) of low and moderate intensity on muscle fiber cross-sectional area and mRNA levels of atrogin-1 and MuRF1 in the mouse tibialis anterior muscle. Six 4-month-old male BALB/c mice (28.5 ± 0.8 g) per group were examined: 1) control, non-sensitized and non-trained (C); 2) ovalbumin sensitized (OA, 20 µg per mouse); 3) non-sensitized and trained at 50% maximum speed _ low intensity (PT50%); 4) non-sensitized and trained at 75% maximum speed _ moderate intensity (PT75%); 5) OA-sensitized and trained at 50% (OA+PT50%), 6) OA-sensitized and trained at 75% (OA+PT75%). There was no difference in muscle fiber cross-sectional area among groups and no difference in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Exercise training; Muscle atrophy; Asthma; Gene expression; Mice. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000400005 |
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| Dalcin,P.T.R.; Piovesan,D.M.; Kang,S.; Fernandes,A.K.; Franciscatto,E.; Millan,T.; Hoffmann,C.; Innocente,C.; Pereira,R.P.; Menna Barreto,S.S.. |
| It is important to identify characteristics related to poor disease control and frequent visits to the emergency department (ED). The objective of the present study was to compare the characteristics of patients attending the adult ED for treatment of asthma exacerbation with those attending an asthma specialist clinic (AC) in the same hospital, and to determine the factors associated with frequent visits to the ED. We conducted a cross-sectional survey of consecutive patients (12 years and older) attending the ED (N = 86) and the AC (N = 86). Significantly more ED patients than AC patients reported ED visits in the past year (95.3 vs 48.8%; P < 0.001) and had difficulty performing work (81.4 vs 49.4%; P < 0.001. Significantly more AC than ED patents... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Asthma; Acute exacerbation; Emergency medicine; Emergency room visits. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000900007 |
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